D.  50847534 Index   <<   >>
 

sieve←{
  b←⍵⍴{∧⌿↑(×/⍵)⍴¨~⍵↑¨1}q←2 3 5
  b[⍳6⌊⍵]←(6⌊⍵)⍴0 0 1 1 0 1 
  49≥⍵:b
  p←(≢q)↓{⍵/⍳⍴⍵}∇⌈⍵*0.5
  m←1+⌊(⍵-1+p×p)÷2×p
  b ⊣ p {b[⍺×⍺+2×⍳⍵]←0}¨ m
}

   +/ sieve 1e9
50847534

•   Mark as not-prime multiples of each prime less than ⍵*0.5 .
Multiples of 2 3 5 are marked by initializing b with ⍵⍴{∧⌿↑(×/⍵)⍴¨~⍵↑¨1}2 3 5 rather than with ⍵⍴1 .
Subsequently, only odd multiples of primes > 5 need to be marked.
Multiples of a prime to be marked can start at its square.